process for production of aciloìnas and process for medication production

NOVELTY – Acyloin production involves forming silicon ether (I) from Morita-Baylis-Hillman (MBH) adduct, where a carboxylic acid (II) is formed from the obtained silicon ether. An isocyanate (III) is obtained from the formed carboxylic acid, where the desired acyloin (IV) is formed from the isocyanate. USE – Method for producing acyloin for manufacturing pharmaceuticals (claimed). ADVANTAGE – The method produces the pharmaceuticals with anti-depressant bupropion. DETAILED DESCRIPTION – Acyloin production involves forming silicon ether of general formula (I) from Morita-Baylis-Hillman (MBH) adduct, where a carboxylic acid of general formula (II) is formed from the obtained silicon ether. An isocyanate of general formula (III) is obtained from the formed carboxylic acid, where the desired acyloin of general formula (IV) is formed from the isocyanate. R1=H, linear or branched 1-7C alkyl, phenyl, optionally substituted with methyl, methoxy, ethyl, ethoxy, Cl, Br, I, OH, NH2 or NO2 group, heterocyclic thiazolyl or thiophenyl; and R2=a protecting group comprising silicon.

Main Application Field

B03 (Other heterocyclics.); B05 (Other organics – aromatics, aliphatic, organo-metallics, compounds whose substituents vary such that they would be classified in several of B01 – B05.)

INVENTORS:

COELHO FERNANDO ANTONIO SANTOS
AMARANTE GIOVANNI WILSON
CAVALLARO MAYRA

281_BUPROPION

Patent number: BR200900158-A2

PATENT STATUS:

For information contact Inova Unicamp

FOR ADDITIONAL INFORMATION:

parcerias@inova.unicamp.br

+55 (19) 3521-5207 / 2607