New 4-anilinequinazoline derivatives as adenosine-kinase inhibitor useful in the treatment of e.g. lesions caused by myocardial or hepatic ischemia, pain

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New 4-anilinequinazoline derivatives as adenosine-kinase inhibitor useful in the treatment of e.g. lesions caused by myocardial or hepatic ischemia, pain

NOVELTY – 4-Anilinequinazoline derivatives are new. USE – For treating lesions caused by myocardiac ischemia in a patient with acute coronary syndrome (myocardium infract and unstable angina) and in a heart-donating patient to preserve the tissue during the period before implantation in the receptor; lesions caused by hepatic ischemia in liver-donating patient; lesions caused by renal ischemia in a kidney-donating patient; lesions caused by cerebral ischemia in a patient in danger of developing cerebral ischemia; lesions caused by chronic inflammatory disease in a patient of rheumatoid arthritis or chronic intestinal inflammatory disease; lesions caused by inflammatory disease in a patient of systemic erythematous lupus; pain caused by cancer, degenerative and chronic inflammatory disease; and also useful for treating or preventing re-stenosis of coronary, renal and iliac arteries in a patient in danger of developing re-stenosis after angioplasty; and atherosclerosis in a patient with an already established atherosclerosis or to prevent its develoment (claimed). ADVANTAGE – The compounds are effective in protection of the myocardium, brain, kidneys and liver from the effect of ischemia/reperfusion. DETAILED DESCRIPTION – 4-Anilinequinazoline derivatives of formula (I) are new. R1 and R2=alkoxy (preferably OCH3); and R3=H, halo, OCH3, CH3, -C(O)CH3, -N(CH3)2 or NO2. R1 – R3 Occupy 3 or 4 position of N-phenyl group, generating meta and para-substituted quinazolinic compounds.

Main Application Field

B02 (Fused ring heterocyclics.)

INVENTORS:

MEIRELLES ANTONIO JOSE DE ALMEIDA
RODRIGUES CHRISTIANNE ELISABETE DA COSTA
GONCALVES CINTIA BERNARDO
BATISTA EDUARDO AUGUSTO CALDAS
KATEKAWA MARCEL EIKI

298_OLEOS VEGETAIS

Patent number: WO2005085213-A1;BR200400869-A;EP1737832-A1;US2007060600-A1;KR2007008605-A;CN1938285-A;IN200605554-P1;MX2006009987-A1;CA2558501-C;EP1737832-B1;CN1938285-B;KR1089493-B1;MX297010-B;US8513267-B2;IN268634-B

PATENT STATUS:

For information contact Inova Unicamp

FOR ADDITIONAL INFORMATION:

parcerias@inova.unicamp.br

+55 (19) 3521-5207 / 2607

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