Polymeric blend or composite used in medical article including prosthetics, and for use in cell immobilization system and controlled release system, comprises alginate and fibroin obtained in form of solidified homogeneous mixture

NOVELTY – The polymeric blend comprises 1-99% of alginate and 1-99% of fibroin obtained in the form of a solidified homogeneous mixture. The solidified homogeneous mixture is obtained by performing electrostatic interaction between alginate and fibroin. A plasticizer is also included in the polymeric blend. USE – Polymeric blend or composite used in medical article including prosthetics, implants, dressings, lenses, and dental or surgical equipments, and for use in cell immobilization system and controlled release system (all claimed). ADVANTAGE – The polymeric blend shows enhanced mechanical and physical properties, water stability, and good biodegradability, and can be prepared in an eco-friendly and cost-effective manner with reduced weight. DETAILED DESCRIPTION – INDEPENDENT CLAIMS are included for the following: (1) a composite, which comprises fibroin fibers dispersed in a polymeric matrix of natural origin; (2) a method for producing a polymeric blend, which involves preparing a solution of alginate and a strong inorganic base, adding a plasticizer into alginate and base solution, and adding a solution of fibroin solution, and then evaporating solvent from the system; and (3) a method for producing composite, which involves preparing a solution of alginate and a strong inorganic base, adding plasticizer in the prepared solution, cutting fibroin fibers uniformly in the prepared solution, and evaporating the solvent from the system. DESCRIPTION OF DRAWING(S) – The drawing shows a schematic optical micrograph of the polymeric blend.

Main Application Field

A11 (Polysaccharides; natural rubber; other natural polymers (only a restricted range of (modified) natural polymers are included. Thus starch would be excluded, but chemically modified starch included).); D21 (Preparations for dental or toilet purposes – including filling alloys, compositions for dentures or dental impressions, anti-caries chewing gum, plaque disclosing compositions, toothpastes, cosmetics, shampoos, topical anti-sunburn compositions and toilet soaps (A61K).); B07 (General – tablets, dispensers, catheters (excluding drainage and angioplasty), encapsulation etc, but not systems for administration of blood or saline or IV feeding etc.); A96 (Medical, dental, veterinary, cosmetic.); D22 (Sterilising, bandages, dressing and skin protection agents – including sterilising agents (other than for food), sutures, plaster casts, bioactive prostheses, contact lenses, diapers, animal litter, timber, preservatives, disinfectants, bactericidal detergents, deodorants, insect repellent compounds, moth proofers, sheep dip (A61L).); B04 (Natural products and polymers. Including testing of body fluids (other than blood typing or cell counting), pharmaceuticals or veterinary compounds of unknown structure, testing of microorganisms for pathogenicity, testing of chemicals for mutagenicity or human toxicity and fermentative production of DNA or RNA. General compositions.); S05 (Electrical Medical Equipment)

INVENTORS:

MASUMI BEPPU MARISA
AGOSTINI DE MORAES MARIANA
FARIAS WESKA RAQUEL

456_SEDA ALGINATO

Patent number: BR201101774-A2

PATENT STATUS:

For information contact Inova Unicamp

FOR ADDITIONAL INFORMATION:

parcerias@inova.unicamp.br

+55 (19) 3521-5207 / 2607