PHARMACEUTICAL COMPOSITION OF AND FORMULATION FOR NON-INVASIVE OCULAR TREATMENT AND ITS USES

With its non-invasive composition and formulation, this eye drop is able to prevent early diabetic retinopathy changes, thus promoting retinal protection.

The currently available interventions for diabetic retinopathy (DR) are invasive, such as laser photocoagulation, intravitreal injections of anti-angiogenic drugs, and vitrectomies. Seeking a less invasive therapeutic option, the present innovation presents an eye drop with a unique composition and formulation that permeates the ocular barriers and reaches the retina. This capability allows the prevention and treatment of retinal changes caused by diabetes or other ocular diseases.

The eye drop of this formulation prevents early markers of diabetic retinopathy (i.e., increased oxidized protein formation and glial reaction) and consequently promotes protective effects of retina function, as observed by electroretinogram tests and immunostaining assays in an experimental diabetic retinopathy model.

MAIN BENEFITS AND CHARACTERISTICS OF THIS INVENTION:

INVENTORES:

• Ophthalmologist, Retinal Specialist
• Former Post-doctoral Fellow at Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
Currently: Senior Researcher, School of Medical Sciences, University of Campinas (UNICAMP), Brazil

MARIA HELENA ANDRADE SANTANA

Full Professor at School of Chemical Engineering, University of Campinas (UNICAMP), Brazil

MARIANA APARECIDA BRUNINI ROSALES

University of Campinas (UNICAMP), Brazil

ALINE BORELLI ALONSO

University of Campinas (UNICAMP), Brazil

SCHOOL/INSTITUTE:

School of Medical Sciences – University of Campinas (UNICAMP), Brazil
School of Chemical Engineering – University of Campinas (UNICAMP), Brazil

PATENT STATUS:

Patent application at the INPI – Brazilian National Institute of Industrial Property (Brazilian Patent Office)

Internal code: 908_RETINOPATIA

FURTHER INFORMATION:

parcerias@inova.unicamp.br

(19) 3521.2607 / 5207