process of polialquileno activated oxide carbonate production and its uses
NOVELTY – Carbonate activated polyalkylene oxide production involves reacting polyalkylene oxide with sodium hydride in presence of an organic solvent to obtain an alkoxide. The polyalkylene oxide and sodium hydride are reacted by using single reactor with constant agitation. The obtained alkoxide is reacted with an organic reagent in presence of co-solvent to obtain a reaction mixture. The obtained reaction mixture is filtrated to separate organic carbonate, and concentrated by evaporation of solvent. The organic carbonate is precipitated to obtain activated carbonate and polyalkylene oxide residue. USE – Method for producing carbonate activated polyalkylene oxide for use as organic macromolecule modifier for use in chemical and pharmaceutical industries (claimed), and for chemical modification of molecules having nucleophilic sites such as proteins, amino acids, peptides, polypeptide, nucleotides, nucleosides, polysaccharides, nitrogen bases, taxanes and their derivatives. ADVANTAGE – The carbonate activated polyalkylene oxide production is easy and produced carbonate activated polyalkylene oxide has low degree of toxicity, thus it is eco-friendly.
Main Application Field
A25 (Polyurethanes; polyethers.); B04 (Natural products and polymers. Including testing of body fluids (other than blood typing or cell counting), pharmaceuticals or veterinary compounds of unknown structure, testing of microorganisms for pathogenicity, testing of chemicals for mutagenicity or human toxicity and fermentative production of DNA or RNA. General compositions.); D16 (Fermentation industry – including fermentation equipment, brewing, yeast production, production of pharmaceuticals and other chemicals by fermentation, microbiology, production of vaccines and antibodies, cell and tissue culture and genetic engineering.); A96 (Medical, dental, veterinary, cosmetic.); B07 (General – tablets, dispensers, catheters (excluding drainage and angioplasty), encapsulation etc, but not systems for administration of blood or saline or IV feeding etc.)
INVENTORS:
SANTANA MARIA HELENA ANDRADE
CORREIA CARLOS ROQUE DUARTE
GOZZO FABIO CESAR
MARTINEZ PABLO DAVID GRIGOL
MACEDO FERNANDA DE MENDONCA
SAITO ELIZA YUKIE
319_CARBONATOS
Patent number: BR200803944-A2
PATENT STATUS:
For information contact Inova Unicamp
FOR ADDITIONAL INFORMATION:
parcerias@inova.unicamp.br
+55 (19) 3521-5207 / 2607
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