Production of intermediates for e.g. fluoxetine synthesis comprises asymmetric catalytic reduction based on oxazaborolidine giving high product yield

NOVELTY – The production of intermediates for e.g. fluoxetine synthesis has asymmetric catalytic reduction via oxazaborolidinee of (+) and (-)-3-exo-amino-7,7-dimethoxynorboman-2-exo-ol. 3-chloro-1-phenyl-1-propanol enriched enantiomerically on recrystallisation in hexane yields the alcohol in 98 per cent enantiomeric excess.

Main Application Field

B05 (Other organics – aromatics, aliphatic, organo-metallics, compounds whose substituents vary such that they would be classified in several of B01 – B05.)

INVENTORS:

PILLI RONALDO ALOISE
LAPIS ALEXANDRE AUGUSTO MOREIRA
COSTA VALENTIM EMILIO UBERTI

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Patent number: BR200306242-A;BR200306242-B1

PATENT STATUS:

GRANTED

FOR ADDITIONAL INFORMATION:

parcerias@inova.unicamp.br

+55 (19) 3521-5207 / 2607