Preparation of 2-bromo-1-(4-nitrophenyl)-1-ethanone, 2-chloro-1-(4-nitrophenyl)-1-ethanone and 2-azido-1-(4-nitrophenyl)-1-ethanone as substrates for bioreductions
NOVELTY – Preparation of 2-bromo-1-(4-nitrophenyl)-1-ethanone, 2-chloro-1-(4-nitrophenyl)-1-ethanone and 2-azido-1-(4-nitrophenyl)-1-ethanone as substrates for bio-reductions and enantioselectively, comprises using cells of Rhodotorula glutinis and Geotrichum candidum or their mutants. USE – Used for the preparation of enantiomers of niphenalol. DETAILED DESCRIPTION – Preparation of 2-bromo-1-(4-nitrophenyl)-1-ethanone, 2-chloro-1-(4-nitrophenyl)-1-ethanone and 2-azido-1-(4-nitrophenyl)-1-ethanone as substrates for bio-reductions, and their products (R)-(-)-2-bromo-1-(4-nitrophenyl)-1-ethanol, (S)-(+)-2-bromo-1-(4-nitrophenyl)-1-ethanol, (R)-(-)-2-chloro-1-(4-nitrophenyl)-1-ethanol, (S)-(+)-2-chloro-1-(4-nitrophenyl)-1-ethanol, (R)-(-)-2-azido-1-(4-nitrophenyl)-1-ethanol and (S)-(+)-2-azido-1-(4-nitrophenyl)-1-ethanol in high chemical performance and enantio selective, using cells of Rhodotorula glutinis and Geotrichum candidum or their mutants.
Main Application Field
B05 (Other organics – aromatics, aliphatic, organo-metallics, compounds whose substituents vary such that they would be classified in several of B01 – B05.); D16 (Fermentation industry – including fermentation equipment, brewing, yeast production, production of pharmaceuticals and other chemicals by fermentation, microbiology, production of vaccines and antibodies, cell and tissue culture and genetic engineering.)
INVENTORS:
RODRIGUES JOSÉ AUGUSTO ROSÁRIO
FARDELONE LUCÍDIO CRISTÓVÃO
MORAN PAULO JOSÉ SAMENHO
59_ETANOL
Patent number: BR200404755-A;BR200404755-B1
PATENT STATUS:
GRANTED
FOR ADDITIONAL INFORMATION:
parcerias@inova.unicamp.br
+55 (19) 3521-5207 / 2607
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