NOVELTY – Recombinant enzyme is described in SEQ ID NO: 1. (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication/). USE – Recombinant enzyme used for enzymatic hydrolysis of epoxide, and vicinal diols used as a key synthetic intermediate in production of drugs used to treat cardiovascular diseases such as hypertension and arrhythmia, and to treat tumors (all claimed). ADVANTAGE – The recombinant enzyme shows 80% yield of vicinal diols with 100% purity.
A97 (Miscellaneous goods not specified elsewhere – including papermaking, gramophone records, detergents, food and oil well applications.); B04 (Natural products and polymers. Including testing of body fluids (other than blood typing or cell counting), pharmaceuticals or veterinary compounds of unknown structure, testing of microorganisms for pathogenicity, testing of chemicals for mutagenicity or human toxicity and fermentative production of DNA or RNA. General compositions.); D16 (Fermentation industry – including fermentation equipment, brewing, yeast production, production of pharmaceuticals and other chemicals by fermentation, microbiology, production of vaccines and antibodies, cell and tissue culture and genetic engineering.)